Gene Expression and Survival of Acute Lymphoblastic Leukemia Cells After Allogeneic Transplant

Background/aim This study explored the mechanisms of allogeneic graft versus leukemia effect in acute lymphoblastic (ALL) cells by examining whether they change gene expression post-transplant environment containing cytokines and immunosuppressant cyclosporine, if such changes affect ALL cell survival. Materials methods RNASeq was used to assess global flow cytometry measure survival presence T cells, NK cytokines, cyclosporine. Results A total 4,805 genes were differentially expressed. Gene set enrichment analysis demonstrated up-regulation biological processes related cytokine responses, control viral infection, regulation leukocyte function including proliferation. Down-regulated mesenchymal tissue morphogenesis. exposed cyclosporine retained susceptibility killing, also exhibited increased death without exposure killer cells. Conclusion significant portion may be mediated